› 6gd2

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-172384 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
ELAV-like protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 87 amino acids
Theoretical weight: 9.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15717 (Residues: 243-326; Coverage: 26%)
Gene names: ELAVL1, HUR
Sequence domains: RNA recognition motif
RNA (5'-R(P*UP*UP*UP*AP*UP*UP*U)-3') Chain: D
Molecule details ›
Chain: D
Length: 15 nucleotides
Theoretical weight: 4.62 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 34.12Å b: 80.48Å c: 54.44Å
α: 90° β: 90.69° γ: 90°
R-values:
R R work R free
0.194 0.192 0.245
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

15 review citations

Understanding and targeting the disease-related RNA binding protein human antigen R (HuR).
Schultz et al. (2020)
14 more

2 mentions without citation

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs.
Pabis et al. (2019)
1 more