› 6iut

X-ray diffraction
2.3Å resolution

Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody AVFluIgG01

Released:
DOI: 10.2210/pdb6iut/pdb
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PDB entry 6iut coloured by chain, front view.
PDB entry 6iut coloured by chain, side view.
PDB entry 6iut coloured by chain, top view.
Source organisms:
Primary publication:
Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1.
Wang P, Zuo Y, Sun J, Zuo T, Zhang S, Guo S, Shi X, Liang M, Zhou P, Zhang L, Wang X
J Biol Chem 294 4290-4303 (2019)
PMID: 30737282

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212086 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
AVFluIgG01 Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 219 amino acids
Theoretical weight: 23.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
AVFluIgG01 Light Chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Hemagglutinin Chain: A

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 112.101Å b: 150.046Å c: 107.968Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.255
Expression systems:
  • Homo sapiens
  • Spodoptera frugiperda

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Citations

2 review citations

Hemagglutinin Structure and Activities.
Gamblin et al. (2021)
1 more

2 mentions without citation

Multiple independent lineages of HIV-1 persist in breast milk and plasma.
Gray et al. (2011)
1 more

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