› 6jgz

Electron Microscopy
4.6Å resolution

Structure of RyR2 (F/P/Ca2+ dataset)

Released:
DOI: 10.2210/pdb6jgz/pdb
PDB entry 6jgz coloured by chain, front view.
PDB entry 6jgz coloured by chain, side view.
PDB entry 6jgz coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.
Chi X, Gong D, Ren K, Zhou G, Huang G, Lei J, Zhou Q, Yan N
OpenAccess logo Proc Natl Acad Sci U S A 116 25575-25582 (2019)
PMID: 31792195
Related structures: EMD-9824

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-549797 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase FKBP1B Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 108 amino acids
Theoretical weight: 11.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68106 (Residues: 1-108; Coverage: 100%)
Gene names: FKBP12.6, FKBP1B, FKBP1L, FKBP9, OTK4
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
RyR2 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 4968 amino acids
Theoretical weight: 564.91 KDa
Source organism: Sus scrofa

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.6Å
Relevant EMDB volumes: EMD-9824
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target.
Dridi et al. (2020)
7 more

2 mentions without citation

Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies.
Ogawa et al. (2021)
1 more