› 6jno

X-ray diffraction
2.65Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor RXR-alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 243 amino acids
Theoretical weight: 27.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 224-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand WY5 1 x WY5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21
Unit cell:
a: 46.615Å b: 99.386Å c: 110.158Å
α: 90° β: 99.42° γ: 90°
R-values:
R R work R free
0.226 0.223 0.274
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Recent applications of computational methods to allosteric drug discovery.
Govindaraj et al. (2022)
4 other articles

5 mentions without citation

Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARĪ±-SREBPs pathway.
He et al. (2022)
4 more