Function and Biology Details
Reactions catalysed:
Acetyl-CoA + n malonyl-CoA + 2n NADPH = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+)
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH
Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]
Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero nonamer (preferred)
Assembly name:
Fatty acid synthase (preferred)
PDBe Complex ID:
PDB-CPX-139404 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fatty acid synthase subunit beta
Molecule details ›
Chains: B, F, G
Length: 2051 amino acids
Theoretical weight: 200.85 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 2051 amino acids
Theoretical weight: 200.85 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
- Canonical:
P07149 (Residues: 1-2051; Coverage: 100%)
Sequence domains:
- N-terminal domain in fatty acid synthase subunit beta
- Starter unit:ACP transacylase in aflatoxin biosynthesis
- Fatty acid synthase subunit beta/Fas1-like, helical
- Fatty acid synthase meander beta sheet domain
- N-terminal half of MaoC dehydratase
- Fatty acid synthase subunit beta, insertion domain
- MaoC like domain
- Acyl transferase domain
Fatty acid synthase subunit alpha
Molecule details ›
Chains: A, D, E
Length: 1887 amino acids
Theoretical weight: 186.48 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
Sequence domains: Beta-ketoacyl synthase, N-terminal domain
Length: 1887 amino acids
Theoretical weight: 186.48 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
- Canonical: P19097 (Residues: 520-1519; Coverage: 53%)
Sequence domains: Beta-ketoacyl synthase, N-terminal domain
Fatty acid synthase subunit alpha
Molecule details ›
Chains: C, H, I
Length: 71 amino acids
Theoretical weight: 8.63 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
Length: 71 amino acids
Theoretical weight: 8.63 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
- Canonical: P19097 (Residues: 1443-1513; Coverage: 4%)
