› 6l53

Electron Microscopy
3.63Å resolution

Structure of SMG1

Released:
DOI: 10.2210/pdb6l53/pdb
PDB entry 6l53 coloured by chain, front view.
PDB entry 6l53 coloured by chain, side view.
PDB entry 6l53 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of SMG1-SMG8-SMG9 complex.
Zhu L, Li L, Qi Y, Yu Z, Xu Y
Cell Res 29 1027-1034 (2019)
PMID: 31729466
Related structures: EMD-0836

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-572543 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase SMG1 Chain: A
Molecule details ›
Chain: A
Length: 3661 amino acids
Theoretical weight: 410.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96Q15 (Residues: 1-3661; Coverage: 100%)
Gene names: ATX, KIAA0421, LIP, SMG1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.63Å
Relevant EMDB volumes: EMD-0836
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Suppression of Nonsense Mutations by New Emerging Technologies.
Morais et al. (2020)
2 more

3 mentions without citation

No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors.
Mailliot et al. (2022)
2 more