6l6r

X-ray diffraction
3.8Å resolution

Crystal structure of LRP6 E1E2-SOST complex

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-131066 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Low-density lipoprotein receptor-related protein 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 622 amino acids
Theoretical weight: 70.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75581 (Residues: 21-630; Coverage: 38%)
Gene name: LRP6
Sequence domains:
Sclerostin Chains: C, D
Molecule details ›
Chains: C, D
Length: 158 amino acids
Theoretical weight: 17.91 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9BQB4 (Residues: 24-177; Coverage: 81%)
Gene names: SOST, UNQ2976/PRO7455/PRO7476
Sequence domains: Sclerostin (SOST)

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, FUC
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P64
Unit cell:
a: 252.792Å b: 252.792Å c: 86.286Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.207 0.256
Expression system: Trichoplusia ni