› 6ljq

X-ray diffraction
1.49Å resolution

human galectin-16 R55N

Released:
DOI: 10.2210/pdb6ljq/pdb
PDB entry 6ljq coloured by chain, front view.
PDB entry 6ljq coloured by chain, side view.
PDB entry 6ljq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity.
Si Y, Yao Y, Jaramillo Ayala G, Li X, Han Q, Zhang W, Xu X, Tai G, Mayo KH, Zhou Y, Su J
Biochim Biophys Acta Gen Subj 1865 129755 (2021)
PMID: 33011338

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-501592 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-16 Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 16.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A8MUM7 (Residues: 1-142; Coverage: 100%)
Gene name: LGALS16
Sequence domains: Galactoside-binding lectin

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: C2
Unit cell:
a: 55.817Å b: 34.333Å c: 67.892Å
α: 90° β: 102.06° γ: 90°
R-values:
R R work R free
0.179 0.176 0.208
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation.
Menkhorst et al. (2021)
9 more