› 6mm1

X-ray diffraction
1.9Å resolution

Structure of the cysteine-rich region from human EHMT2

Released:
DOI: 10.2210/pdb6mm1/pdb
PDB entry 6mm1 coloured by chain, front view.
PDB entry 6mm1 coloured by chain, side view.
PDB entry 6mm1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a).
Kerchner KM, Mou TC, Sun Y, Rusnac DV, Sprang SR, Briknarová K
OpenAccess logo J Struct Biol X 5 100050 (2021)
PMID: 34278292

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(9)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase EHMT2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 136 amino acids
Theoretical weight: 14.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96KQ7 (Residues: 419-552; Coverage: 11%)
Gene names: BAT8, C6orf30, EHMT2, G9A, KMT1C, NG36
Sequence domains: Histone-lysine N-methyltransferase EHMT1/EHMT2, Cys-rich region

Ligands and Environments

1 bound ligand:
Ligand ZN 16 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: null, SSRL BEAMLINE BL12-2, APS BEAMLINE 19-BM
Spacegroup: P1
Unit cell:
a: 47.996Å b: 54.358Å c: 59.317Å
α: 91.68° β: 100.92° γ: 96.89°
R-values:
R R work R free
0.176 0.174 0.223
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Identification and validation of the reference genes in the echiuran worm Urechis unicinctus based on transcriptome data.
Chen et al. (2023)
1 more

2 mentions without citation

A bioinformatics investigation into molecular mechanism of Yinzhihuang granules for treating hepatitis B by network pharmacology and molecular docking verification.
Zhang et al. (2020)
1 more