› 6moh

X-ray diffraction
3.2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148532 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dimeric DARPin E2C (C_R3) Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 17.57 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Erythropoietin receptor Chains: C, D
Molecule details ›
Chains: C, D
Length: 229 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19235 (Residues: 32-249; Coverage: 45%)
Gene name: EPOR
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand PO4 7 x PO4
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P43212
Unit cell:
a: 96.193Å b: 96.193Å c: 286.401Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.277
Expression systems:
  • Escherichia coli
  • Trichoplusia ni

Quick links

Citations

14 review citations

Recent advances in de novo protein design: Principles, methods, and applications.
Pan et al. (2021)
13 more

2 mentions without citation

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Mohan et al. (2019)
1 more