6nbh

Electron Microscopy
3.5Å resolution

Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-528854 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Parathyroid hormone/parathyroid hormone-related peptide receptor Chain: R
Molecule details ›
Chain: R
Length: 478 amino acids
Theoretical weight: 54.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q03431 (Residues: 27-502; Coverage: 84%)
Gene names: PTH1R, PTHR, PTHR1
Sequence domains:
Long-acting parathyroid hormone analog Chain: P
Molecule details ›
Chain: P
Length: 36 amino acids
Theoretical weight: 4.27 KDa
Source organism: Homo sapiens
Expression system: synthetic construct
Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Nanobody-35 Chain: N

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-0411
Expression systems:
  • Spodoptera
  • synthetic construct
  • Escherichia coli