› 6nih

X-ray diffraction
2.3Å resolution

Crystal structure of human TLR1

Released:
DOI: 10.2210/pdb6nih/pdb
PDB entry 6nih coloured by chain, front view.
PDB entry 6nih coloured by chain, side view.
PDB entry 6nih coloured by chain, top view.
Source organisms:
Primary publication:
Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim.
Su L, Wang Y, Wang J, Mifune Y, Morin MD, Jones BT, Moresco EMY, Boger DL, Beutler B, Zhang H
J Med Chem 62 2938-2949 (2019)
PMID: 30829478

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172277 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
LRRNT domain-containing protein; Toll-like receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 545 amino acids
Theoretical weight: 62.35 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15399 (Residues: 1-475; Coverage: 59%)
  • Canonical: Q2YDZ3 (Residues: 156-224; Coverage: 25%)
Gene names: KIAA0012, TLR1, VLRB
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 79.028Å b: 74.377Å c: 106.076Å
α: 90° β: 96.97° γ: 90°
R-values:
R R work R free
0.245 0.244 0.274
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

Pattern recognition receptors in health and diseases.
Li et al. (2021)
8 more

18 mentions without citation

Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma.
Xun et al. (2021)
17 more