› 6nr9

Electron Microscopy
8.5Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 22-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-518408 (preferred)
Entry contents:
14 distinct polypeptide molecules
Macromolecules (14 distinct):
T-complex protein 1 subunit alpha Chains: A, I
Molecule details ›
Chains: A, I
Length: 534 amino acids
Theoretical weight: 58.06 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P17987 (Residues: 1-534; Coverage: 96%)
Gene names: CCT1, CCTA, TCP1
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit beta Chains: B, J
Molecule details ›
Chains: B, J
Length: 509 amino acids
Theoretical weight: 54.74 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P78371 (Residues: 16-524; Coverage: 95%)
Gene names: 99D8.1, CCT2, CCTB
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit gamma Chains: C, K
Molecule details ›
Chains: C, K
Length: 513 amino acids
Theoretical weight: 57.17 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P49368 (Residues: 13-525; Coverage: 94%)
Gene names: CCT3, CCTG, TRIC5
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit delta Chains: D, L
Molecule details ›
Chains: D, L
Length: 514 amino acids
Theoretical weight: 55.64 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P50991 (Residues: 26-539; Coverage: 95%)
Gene names: CCT4, CCTD, SRB
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit epsilon Chains: E, M
Molecule details ›
Chains: E, M
Length: 517 amino acids
Theoretical weight: 56.99 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P48643 (Residues: 25-541; Coverage: 96%)
Gene names: CCT5, CCTE, KIAA0098
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit zeta Chains: F, N
Molecule details ›
Chains: F, N
Length: 515 amino acids
Theoretical weight: 56.45 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P40227 (Residues: 11-525; Coverage: 97%)
Gene names: CCT6, CCT6A, CCTZ
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit eta Chains: G, O
Molecule details ›
Chains: G, O
Length: 514 amino acids
Theoretical weight: 56.37 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q99832 (Residues: 12-525; Coverage: 95%)
Gene names: CCT7, CCTH, NIP7-1
Sequence domains: TCP-1/cpn60 chaperonin family
T-complex protein 1 subunit theta Chains: H, P
Molecule details ›
Chains: H, P
Length: 514 amino acids
Theoretical weight: 56.1 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P50990 (Residues: 14-527; Coverage: 94%)
Gene names: C21orf112, CCT8, CCTQ, KIAA0002
Sequence domains: TCP-1/cpn60 chaperonin family
Prefoldin subunit 1 Chain: 1
Molecule details ›
Chain: 1
Length: 107 amino acids
Theoretical weight: 12.52 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: O60925 (Residues: 12-118; Coverage: 88%)
Gene names: PFD1, PFDN1
Sequence domains: Prefoldin subunit
Prefoldin subunit 2 Chain: 2
Molecule details ›
Chain: 2
Length: 103 amino acids
Theoretical weight: 11.86 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q9UHV9 (Residues: 22-124; Coverage: 67%)
Gene names: HSPC231, PFD2, PFDN2
Sequence domains: Prefoldin subunit
Prefoldin subunit 3 Chain: 3
Molecule details ›
Chain: 3
Length: 132 amino acids
Theoretical weight: 15.56 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P61758 (Residues: 49-180; Coverage: 67%)
Gene names: PFDN3, VBP1
Sequence domains: Prefoldin subunit
Prefoldin subunit 4 Chain: 4
Molecule details ›
Chain: 4
Length: 104 amino acids
Theoretical weight: 12.14 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q9NQP4 (Residues: 19-122; Coverage: 78%)
Gene names: PFD4, PFDN4
Sequence domains: Prefoldin subunit
Prefoldin subunit 5 Chain: 5
Molecule details ›
Chain: 5
Length: 127 amino acids
Theoretical weight: 14.58 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q99471 (Residues: 11-137; Coverage: 83%)
Gene names: MM1, PFD5, PFDN5
Sequence domains: Prefoldin subunit
Prefoldin subunit 6 Chain: 6
Molecule details ›
Chain: 6
Length: 102 amino acids
Theoretical weight: 11.78 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: O15212 (Residues: 13-114; Coverage: 79%)
Gene names: HKE2, PFD6, PFDN6
Sequence domains: Prefoldin subunit

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 8.5Å
Relevant EMDB volumes: EMD-0491
Expression system: Insect cell expression vector pTIE1

Quick links

Citations

10 review citations

The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response.
Lang et al. (2021)
9 more

1 mention without citation

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
Gestaut et al. (2019)