› 6oeu

Electron Microscopy
3.5Å resolution

Structure of human Patched1

Released:
DOI: 10.2210/pdb6oeu/pdb
PDB entry 6oeu coloured by chain, front view.
PDB entry 6oeu coloured by chain, side view.
PDB entry 6oeu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Qi X, Schmiege P, Coutavas E, Wang J, Li X
Nature 560 128-132 (2018)
PMID: 29995851
Related structures: EMD-7795

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171795 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Protein patched homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 1455 amino acids
Theoretical weight: 161.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13635 (Residues: 1-1447; Coverage: 100%)
Gene names: PTCH, PTCH1
Sequence domains: Patched family

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-7795
Expression system: Homo sapiens

Quick links

Citations

40 review citations

Cellular signalling by primary cilia in development, organ function and disease.
Anvarian et al. (2019)
39 more

6 mentions without citation

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.
Alav et al. (2021)
5 more