› 6p6d

X-ray diffraction
2.31Å resolution

HUMAN IGG1 FC FRAGMENT, C239 INSERTION MUTANT

Released:
DOI: 10.2210/pdb6p6d/pdb
PDB entry 6p6d coloured by chain, front view.
PDB entry 6p6d coloured by chain, side view.
PDB entry 6p6d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions.
Gallagher DT, McCullough C, Brinson RG, Ahn J, Marino JP, Dimasi N
OpenAccess logo Pharmaceutics 11 (2019)
PMID: 31640157

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-534181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin gamma-1 heavy chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 228 amino acids
Theoretical weight: 25.72 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P0DOX5 (Residues: 223-241, 242-449; Coverage: 51%)
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
1 bound ligand:
Ligand CYS 2 x CYS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 50.192Å b: 81.066Å c: 136.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.223 0.268
Expression system: Cricetulus griseus

Quick links

Citations

1 review citation

Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems.
James et al. (2022)
1 other article

2 mentions without citation

Structural and Biochemical Characterization of Cysteinylation in Broadly Neutralizing Antibodies to HIV-1.
Omorodion et al. (2021)
1 more