6q0w

X-ray diffraction
2.9Å resolution

Structure of DDB1-DDA1-DCAF15 complex bound to Indisulam and RBM39

Released:
Model geometry
Data not analysed
Fit model/data
Data not analysed

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-172015 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
DNA damage-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 864 amino acids
Theoretical weight: 96.43 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q16531 (Residues: 1-395, 706-1140; Coverage: 73%)
  • Best match: Q16531-2 (Residues: 59-451)
Gene names: DDB1, XAP1
Sequence domains:
DDB1- and CUL4-associated factor 15 Chain: B
Molecule details ›
Chain: B
Length: 276 amino acids
Theoretical weight: 31.61 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q66K64 (Residues: 34-260; Coverage: 38%)
Gene names: C19orf72, DCAF15
Sequence domains: DDB1-and CUL4-substrate receptor 15, WD repeat
DDB1- and CUL4-associated factor 15 Chain: C
RNA-binding protein 39 Chain: D
DET1- and DDB1-associated protein 1 Chain: E

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 93.973Å b: 81.799Å c: 260.978Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.238 0.264
Expression system: Trichoplusia ni