› 6qm7

Electron Microscopy
2.8Å resolution

Function and Biology Details

Reaction catalysed: 
Cleavage of peptide bonds with very broad specificity.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 28-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104710 (preferred)
Entry contents:
14 distinct polypeptide molecules
Macromolecules (14 distinct):
Proteasome subunit alpha type Chains: A, O
Molecule details ›
Chains: A, O
Length: 250 amino acids
Theoretical weight: 27.18 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: A0A6L0XSJ0 (Residues: 1-250; Coverage: 100%)
Gene name: LINJ_35_4910
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit alpha type Chains: B, P
Molecule details ›
Chains: B, P
Length: 231 amino acids
Theoretical weight: 25.18 KDa
Source organism: Leishmania tarentolae
UniProt:
  • Canonical: Q9GNZ8 (Residues: 1-231; Coverage: 100%)
Gene name: LINJ_21_2070
Sequence domains:
Proteasome subunit alpha type Chains: C, Q
Proteasome subunit alpha type Chains: D, R
Proteasome subunit alpha type Chains: E, S
Proteasome subunit alpha type Chains: F, T
Proteasome alpha-type subunits domain-containing protein Chains: G, U
Proteasome subunit beta Chains: H, V
Proteasome subunit beta Chains: I, W
Proteasome subunit beta Chains: J, X
Proteasome subunit beta Chains: K, Y
Proteasome subunit beta Chains: L, Z
Proteasome subunit beta Chains: M, a
Proteasome subunit beta Chains: N, b

Ligands and Environments

1 bound ligand:
Ligand J6E 2 x J6E
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.8Å
Relevant EMDB volumes: EMD-4590

Quick links

Citations

17 review citations

An Overview on the Therapeutics of Neglected Infectious Diseases-Leishmaniasis and Chagas Diseases.
J et al. (2021)
16 more

9 mentions without citation

Ubiquitination and the Proteasome as Drug Targets in Trypanosomatid Diseases.
Bijlmakers MJ. (2020)
8 more