› 6r99

X-ray diffraction
2.7Å resolution

Crystal Structure of Human CLN protein 5 (Ceroid Lipofuscinosis Neuronal Protein 5)

Released:
DOI: 10.2210/pdb6r99/pdb
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PDB entry 6r99 coloured by chain, front view.
PDB entry 6r99 coloured by chain, side view.
PDB entry 6r99 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration.
Luebben AV, Bender D, Becker S, Crowther LM, Erven I, Hofmann K, Söding J, Klemp H, Bellotti C, Stäuble A, Qiu T, Kathayat RS, Dickinson BC, Gärtner J, Sheldrick GM, Krätzner R, Steinfeld R
OpenAccess logo Sci Adv 8 eabj8633 (2022)
PMID: 35427157

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-228136 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Ceroid-lipofuscinosis neuronal protein 5 Chain: A
Molecule details ›
Chain: A
Length: 407 amino acids
Theoretical weight: 46.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
1 modified residue:
Ligand MSE 11 x MSE

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 58.42Å b: 58.42Å c: 179.05Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.221 0.247
Expression system: Homo sapiens

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Citations

2 review citations

Converging links between adult-onset neurodegenerative Alzheimer's disease and early life neurodegenerative neuronal ceroid lipofuscinosis?
Klein et al. (2023)
1 more

2 mentions without citation

A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis.
Basak et al. (2021)
1 more

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