6rne

X-ray diffraction
1.65Å resolution

DPP1 in complex with inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-156841 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Dipeptidyl peptidase 1 exclusion domain chain Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 25-143; Coverage: 27%)
Gene names: CPPI, CTSC
Sequence domains: Cathepsin C exclusion domain
Dipeptidyl peptidase 1 heavy chain Chain: B
Molecule details ›
Chain: B
Length: 165 amino acids
Theoretical weight: 18.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 230-394; Coverage: 38%)
Gene names: CPPI, CTSC
Sequence domains: Papain family cysteine protease
Dipeptidyl peptidase 1 light chain Chain: C
Molecule details ›
Chain: C
Length: 69 amino acids
Theoretical weight: 7.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53634 (Residues: 395-463; Coverage: 16%)
Gene names: CPPI, CTSC

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: I222
Unit cell:
a: 87.542Å b: 87.74Å c: 114.551Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.203
Expression system: Spodoptera frugiperda