6rpb

X-ray diffraction
2.5Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-528358 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
HLA class I histocompatibility antigen, A alpha chain Chains: A, F, K, P
Molecule details ›
Chains: A, F, K, P
Length: 277 amino acids
Theoretical weight: 32.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Beta-2-microglobulin Chains: B, G, L, Q
Molecule details ›
Chains: B, G, L, Q
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Cancer/testis antigen 1 Chains: C, H, M, R
Molecule details ›
Chains: C, H, M, R
Length: 9 amino acids
Theoretical weight: 1.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P78358 (Residues: 157-164; Coverage: 4%)
Gene names: CTAG, CTAG1, CTAG1A, CTAG1B, ESO1, LAGE2, LAGE2A, LAGE2B
T-cell receptor alpha chain Chains: D, I, N, S
Molecule details ›
Chains: D, I, N, S
Length: 206 amino acids
Theoretical weight: 22.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
T-cell receptor beta chain Chains: E, J, O, T
Molecule details ›
Chains: E, J, O, T
Length: 244 amino acids
Theoretical weight: 27.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P1
Unit cell:
a: 75.342Å b: 77.134Å c: 184.632Å
α: 93.02° β: 93.45° γ: 108.16°
R-values:
R R work R free
0.25 0.249 0.273
Expression systems:
  • Escherichia coli
  • Not provided