› 6s0a

X-ray diffraction
2.52Å resolution

Crystal Structure of Properdin (TSR domains N12 & 456)

Released:
DOI: 10.2210/pdb6s0a/pdb
PDB entry 6s0a coloured by chain, front view.
PDB entry 6s0a coloured by chain, side view.
PDB entry 6s0a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
van den Bos RM, Pearce NM, Granneman J, Brondijk THC, Gros P
OpenAccess logo Front Immunol 10 2097 (2019)
PMID: 31552043

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151103 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Properdin Chain: A
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 25.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P27918 (Residues: 256-469; Coverage: 48%)
Gene names: CFP, PFC
Sequence domains:
Properdin Chain: B
Molecule details ›
Chain: B
Length: 166 amino acids
Theoretical weight: 17.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P27918 (Residues: 26-191; Coverage: 37%)
Gene names: CFP, PFC
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: FUC, BGC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand MAN 10 x MAN
Ligand FUC 1 x FUC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: I422
Unit cell:
a: 114.753Å b: 114.753Å c: 232.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.248 0.267
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Complement component C3: A structural perspective and potential therapeutic implications.
Geisbrecht et al. (2022)
3 more

3 mentions without citation

Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond.
Pedersen et al. (2023)
2 more