› 6tdc

X-ray diffraction
2.33Å resolution

PPAR gamma ligand binding domain in complex with MRL-871

Released:
DOI: 10.2210/pdb6tdc/pdb
PDB entry 6tdc coloured by chain, front view.
PDB entry 6tdc coloured by chain, side view.
PDB entry 6tdc coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: de Vries RMJM, Leijten-van de Gevel IA, van Herk KHN, Brunsveld L

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 235-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

2 bound ligands:
Ligand 4F1 1 x 4F1
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: P6322
Unit cell:
a: 93.142Å b: 93.142Å c: 130.574Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.201 0.239
Expression system: Escherichia coli

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