6tnq

X-ray diffraction
1.3Å resolution

Crystal structure of the human Arc N-lobe bound to repeat 4 from GKAP

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-126977 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activity-regulated cytoskeleton-associated protein Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 75 amino acids
Theoretical weight: 8.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7LC44 (Residues: 207-277; Coverage: 18%)
Gene names: ARC, KIAA0278
Sequence domains: Activity-regulated cytoskeleton-associated protein, capsid domain
Disks large-associated protein 1 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 8 amino acids
Theoretical weight: 981 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14490 (Residues: 430-437; Coverage: 1%)
Gene names: DAP1, DLGAP1, GKAP

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P21
Unit cell:
a: 50.8Å b: 29.37Å c: 71.36Å
α: 90° β: 93.4° γ: 90°
R-values:
R R work R free
0.132 0.132 0.17
Expression systems:
  • Escherichia coli
  • Not provided