› 6tqf

Electron Microscopy
3.5Å resolution

The structure of ABC transporter Rv1819c in AMP-PNP bound state

Released:
DOI: 10.2210/pdb6tqf/pdb
PDB entry 6tqf coloured by chain, front view.
PDB entry 6tqf coloured by chain, side view.
PDB entry 6tqf coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.
Rempel S, Gati C, Nijland M, Thangaratnarajah C, Karyolaimos A, de Gier JW, Guskov A, Slotboom DJ
Nature 580 409-412 (2020)
PMID: 32296172
Related structures: EMD-10550

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162079 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hydrophilic compounds import ATP-binding/permease protein BacA Chains: A, B
Molecule details ›
Chains: A, B
Length: 647 amino acids
Theoretical weight: 72.42 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WQI9 (Residues: 1-639; Coverage: 100%)
Gene names: MTCY1A11.24c, Rv1819c, bacA
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand LMT 10 x LMT
Ligand MG 2 x MG
Ligand ANP 2 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-10550
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Sharing vitamins: Cobamides unveil microbial interactions.
Sokolovskaya et al. (2020)
8 more

6 mentions without citation

Structural and functional diversity calls for a new classification of ABC transporters.
Thomas et al. (2020)
5 more