› 6u6i

Electron Microscopy
3.12Å resolution

NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in asymmetric global conformation

Released:
DOI: 10.2210/pdb6u6i/pdb
PDB entry 6u6i coloured by chain, front view.
PDB entry 6u6i coloured by chain, side view.
PDB entry 6u6i coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
Nakagawa T
Science 366 1259-1263 (2019)
PMID: 31806817
Related structures: EMD-20666

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 889 amino acids
Theoretical weight: 99.53 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 1-868; Coverage: 98%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-20666
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
8 more

1 mention without citation

AMPA receptor structure and auxiliary subunits.
Kamalova et al. (2021)