6ud7

X-ray diffraction
2.3Å resolution

Crystal structure of full-length human DCAF15-DDB1(deltaBPB)-DDA1-RBM39 in complex with indisulam

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-172016 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
DDB1- and CUL4-associated factor 15 Chain: A
Molecule details ›
Chain: A
Length: 601 amino acids
Theoretical weight: 66.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q66K64 (Residues: 2-600; Coverage: 100%)
Gene names: C19orf72, DCAF15
Sequence domains: DDB1-and CUL4-substrate receptor 15, WD repeat
DNA damage-binding protein 1 Chain: B
Molecule details ›
Chain: B
Length: 836 amino acids
Theoretical weight: 93.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16531 (Residues: 1-395, 706-1140; Coverage: 73%)
  • Best match: Q16531-2 (Residues: 59-451)
Gene names: DDB1, XAP1
Sequence domains:
RNA-binding protein 39 Chain: C
DET1- and DDB1-associated protein 1 Chain: D

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 81.032Å b: 93.778Å c: 264.639Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.248
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli