› 6ugk

X-ray diffraction
2.15Å resolution

CRYSTAL STRUCTURE OF CIRCULARLY PERMUTED HUMAN TASPASE-1

Released:
DOI: 10.2210/pdb6ugk/pdb
Model geometry
Data not analysed
Fit model/data
Data not analysed
PDB entry 6ugk coloured by chain, front view.
PDB entry 6ugk coloured by chain, side view.
PDB entry 6ugk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the function of the catalytically active human Taspase1.
Nagaratnam N, Delker SL, Jernigan R, Edwards TE, Snider J, Thifault D, Williams D, Nannenga BL, Stofega M, Sambucetti L, Hsieh JJ, Flint AJ, Fromme P, Martin-Garcia JM
Structure 29 873-885.e5 (2021)
PMID: 33784495

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190639 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Threonine aspartase subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 35.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H6P5 (Residues: 234-416; Coverage: 44%)
Gene names: C20orf13, TASP1
Sequence domains: Asparaginase

Ligands and Environments

2 bound ligands:
Ligand NA 2 x NA
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P65
Unit cell:
a: 60.3Å b: 60.3Å c: 319.01Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.161 0.159 0.197
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 citation in other articles

Closantel is an allosteric inhibitor of human Taspase1.
Luciano et al. (2021)
2 more

PDB-REDO

The sliders below show the change in model quality between original PDB entry and the PDB-REDO entry

Model Geometry
 
 
Data not available
DNA/RNA Geometry
 
 
Data not available
Fit model/data
 
 
Data not available
PDB-REDO