› 6uqg

Electron Microscopy
3.54Å resolution

Human HCN1 channel Y289D mutant

Released:
DOI: 10.2210/pdb6uqg/pdb
PDB entry 6uqg coloured by chain, front view.
PDB entry 6uqg coloured by chain, side view.
PDB entry 6uqg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Voltage Sensor Movements during Hyperpolarization in the HCN Channel.
Lee CH, MacKinnon R
Cell 179 1582-1589.e7 (2019)
PMID: 31787376
Related structures: EMD-20847

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-521156 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 660 amino acids
Theoretical weight: 74.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60741 (Residues: 1-890; Coverage: 74%)
Gene names: BCNG1, HCN1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CMP 4 x CMP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.54Å
Relevant EMDB volumes: EMD-20847
Expression system: Homo sapiens

Quick links

Citations

9 review citations

The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating.
Barros et al. (2020)
8 more

5 mentions without citation

Strategies for Overcoming the Single-Molecule Concentration Barrier.
White et al. (2023)
4 more