› 6v8x

Electron Microscopy
3Å resolution

VRC01 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure

Released:
DOI: 10.2210/pdb6v8x/pdb
PDB entry 6v8x coloured by chain, front view.
PDB entry 6v8x coloured by chain, side view.
PDB entry 6v8x coloured by chain, top view.
Source organisms:
Primary publication:
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.
Henderson R, Lu M, Zhou Y, Mu Z, Parks R, Han Q, Hsu AL, Carter E, Blanchard SC, Edwards RJ, Wiehe K, Saunders KO, Borgnia MJ, Bartesaghi A, Mothes W, Haynes BF, Acharya P, Munir Alam S
OpenAccess logo Nat Commun 11 520 (2020)
PMID: 31980614
Related structures: EMD-21111

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-173834 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (7 distinct):
Envelope glycoprotein gp160 Chains: A, E, I
Molecule details ›
Chains: A, E, I
Length: 471 amino acids
Theoretical weight: 52.79 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 32-502; Coverage: 55%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Transmembrane protein gp41 Chains: B, F, J
Molecule details ›
Chains: B, F, J
Length: 145 amino acids
Theoretical weight: 16.45 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S9 (Residues: 519-663; Coverage: 17%)
Gene name: env
Sequence domains: Retroviral envelope protein
Ig-like domain-containing protein Chains: C, G, K
Molecule details ›
Chains: C, G, K
Length: 224 amino acids
Theoretical weight: 24.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6N095 (Residues: 20-248; Coverage: 49%)
Gene name: DKFZp686K03196
Sequence domains:
Ig-like domain-containing protein Chains: D, H, L
Molecule details ›
Chains: D, H, L
Length: 208 amino acids
Theoretical weight: 22.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PIL8 (Residues: 23-126, 127-236; Coverage: 95%)
Gene name: IGK@
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 15 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-21111
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?
Klasse et al. (2020)
8 more

4 mentions without citation

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.
Antanasijevic et al. (2021)
3 more