› 6vgc

X-ray diffraction
2.37Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148927 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arachidonate 5-lipoxygenase-activating protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 171 amino acids
Theoretical weight: 19.33 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P20292 (Residues: 2-161; Coverage: 99%)
Gene names: ALOX5AP, FLAP
Sequence domains: MAPEG family

Ligands and Environments

3 bound ligands:
Ligand QY1 6 x QY1
Ligand CA 2 x CA
Ligand BOG 1 x BOG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21
Unit cell:
a: 65.911Å b: 101.488Å c: 111.864Å
α: 90° β: 99.83° γ: 90°
R-values:
R R work R free
0.255 0.254 0.285
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators.
Gilbert et al. (2021)
2 other articles

3 mentions without citation

Identification of 2,4-Dinitro-Biphenyl-Based Compounds as MAPEG Inhibitors.
Di Micco et al. (2022)
2 more