› 6vz0

X-ray diffraction
1.75Å resolution

C-terminal domain of mouse surfactant protein B crystallized at high pH

Released:
DOI: 10.2210/pdb6vz0/pdb
PDB entry 6vz0 coloured by chain, front view.
PDB entry 6vz0 coloured by chain, side view.
PDB entry 6vz0 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
Sever N, Miličić G, Bodnar NO, Wu X, Rapoport TA
Mol Cell 81 49-66.e8 (2021)
PMID: 33242393

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156175 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pulmonary surfactant-associated protein B Chains: A, B
Molecule details ›
Chains: A, B
Length: 77 amino acids
Theoretical weight: 8.75 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P50405 (Residues: 292-367; Coverage: 21%)
Gene names: Sftp3, Sftpb
Sequence domains: Saposin-like type B, region 2

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 38.396Å b: 58.36Å c: 64.673Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.212
Expression system: Escherichia coli

Quick links

Citations

4 review citations

A recipe for a good clinical pulmonary surfactant.
Pérez-Gil J. (2022)
3 more

1 mention without citation

Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
Sever et al. (2021)