6vzi

X-ray diffraction
2.72Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octadecamer (preferred)
PDBe Complex ID:
PDB-CPX-231537 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (10 distinct):
Transmembrane protein gp41 Chain: B
Molecule details ›
Chain: B
Length: 154 amino acids
Theoretical weight: 17.32 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: W6ICH7 (Residues: 504-657; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
35O22 scFv heavy chain Chain: D
Molecule details ›
Chain: D
Length: 134 amino acids
Theoretical weight: 14.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
35O22 scFv light chain Chain: E
Molecule details ›
Chain: E
Length: 114 amino acids
Theoretical weight: 12.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Envelope glycoprotein gp160 Chain: G
Molecule details ›
Chain: G
Length: 471 amino acids
Theoretical weight: 53.42 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0N9FF17 (Residues: 29-493; Coverage: 55%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
3H109L Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 244 amino acids
Theoretical weight: 26.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
3H109L Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 217 amino acids
Theoretical weight: 23.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P63
Unit cell:
a: 133.92Å b: 133.92Å c: 315.11Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.229 0.276
Expression system: Homo sapiens