› 6wdp

X-ray diffraction
2.01Å resolution

Interleukin 12 receptor subunit beta-1

Released:
DOI: 10.2210/pdb6wdp/pdb
Model geometry
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PDB entry 6wdp coloured by chain, front view.
PDB entry 6wdp coloured by chain, side view.
PDB entry 6wdp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC
Cell 184 983-999.e24 (2021)
PMID: 33606986

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154856 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-12 receptor subunit beta-1 Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 24.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P42701 (Residues: 27-239; Coverage: 33%)
Gene names: IL12R, IL12RB, IL12RB1

Ligands and Environments

2 bound ligands:
Ligand GOL 3 x GOL
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.2.2, SSRL BEAMLINE BL12-2
Spacegroup: P43212
Unit cell:
a: 55.78Å b: 55.78Å c: 182.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.222 0.242
Expression system: Trichoplusia ni

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Citations

22 review citations

Emerging principles of cytokine pharmacology and therapeutics.
Saxton et al. (2023)
21 more

1 mention without citation

Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Glassman et al. (2021)

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