Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Interleukin-23 receptor-ligand complex (preferred)
PDBe Complex ID:
PDB-CPX-279895 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (6 distinct):
Interleukin-12 subunit beta
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 34.91 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Cytokine interleukin-12p40 C-terminus
Length: 308 amino acids
Theoretical weight: 34.91 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P29460 (Residues: 21-328; Coverage: 100%)
Sequence domains: Cytokine interleukin-12p40 C-terminus
Interleukin-23 subunit alpha
Molecule details ›
Chain: B
Length: 171 amino acids
Theoretical weight: 19.1 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Interleukin 23 subunit alpha
Length: 171 amino acids
Theoretical weight: 19.1 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: Q9NPF7 (Residues: 28-189; Coverage: 95%)
Sequence domains: Interleukin 23 subunit alpha
Interleukin-23 receptor
Molecule details ›
Chain: C
Length: 307 amino acids
Theoretical weight: 35.67 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt: Gene name: IL23R
Length: 307 amino acids
Theoretical weight: 35.67 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt: Gene name: IL23R
Interleukin-12 receptor subunit beta-1
Molecule details ›
Chain: D
Length: 219 amino acids
Theoretical weight: 24.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Length: 219 amino acids
Theoretical weight: 24.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: P42701 (Residues: 27-239; Coverage: 33%)
