6whz

X-ray diffraction
2.9Å resolution

Function and Biology Details

Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-553487 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone deacetylase 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 385 amino acids
Theoretical weight: 43.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
U2M-ASN-HYP-LYS-GLN-DLY-TRP-GLY peptide macrocycle Chains: D, F, G
Molecule details ›
Chains: D, F, G
Length: 8 amino acids
Theoretical weight: 1.03 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 92.477Å b: 94.802Å c: 138.813Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.227 0.281
Expression systems:
  • Spodoptera frugiperda
  • Not provided