› 6wk0

X-ray diffraction
2Å resolution

Crystal structure of human ribokinase in complex with AMPPCP and ribose

Released:
DOI: 10.2210/pdb6wk0/pdb
PDB entry 6wk0 coloured by chain, front view.
PDB entry 6wk0 coloured by chain, side view.
PDB entry 6wk0 coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Park J

Function and Biology Details

Reaction catalysed: 
ATP + D-ribose = ADP + D-ribose 5-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190599 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribokinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 317 amino acids
Theoretical weight: 33.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H477 (Residues: 14-322; Coverage: 96%)
Gene names: RBKS, RBSK
Sequence domains: pfkB family carbohydrate kinase

Ligands and Environments

3 bound ligands:
Ligand ACP 4 x ACP
Ligand NA 8 x NA
Ligand RIB 2 x RIB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 52.02Å b: 89.35Å c: 144.7Å
α: 90° β: 98.61° γ: 90°
R-values:
R R work R free
0.199 0.197 0.239
Expression system: Escherichia coli BL21(DE3)

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