› 6xcp

X-ray diffraction
3.3Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208063 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 193 amino acids
Theoretical weight: 21.93 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q30069 (Residues: 1-184; Coverage: 81%)
Gene name: HLA-DQA1
Sequence domains:
Ig-like domain-containing protein Chain: C
Molecule details ›
Chain: C
Length: 230 amino acids
Theoretical weight: 26.07 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O19707 (Residues: 1-192; Coverage: 84%)
Gene name: HLA-DQB1
Sequence domains:
T-CELL-RECEPTOR, A2.13-alpha chain Chain: D
Molecule details ›
Chain: D
Length: 203 amino acids
Theoretical weight: 22.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
T-CELL-RECEPTOR, A2.13-beta chain Chain: E
Molecule details ›
Chain: E
Length: 240 amino acids
Theoretical weight: 27.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)

Ligands and Environments

3 bound ligands:
Ligand NAG 2 x NAG
Ligand GOL 1 x GOL
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 65.977Å b: 116.788Å c: 124.187Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.268
Expression systems:
  • Trichoplusia ni
  • Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Neoantigens: promising targets for cancer therapy.
Xie et al. (2023)
4 more