› 6xol

X-ray diffraction
2.39Å resolution

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DCN1-like protein 1; Endolysin Chain: A
Molecule details ›
Chain: A
Length: 386 amino acids
Theoretical weight: 44.35 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: D9IEF7 (Residues: 1-164; Coverage: 100%)
  • Canonical: Q96GG9 (Residues: 62-259; Coverage: 76%)
Gene names: DCN1, DCUN1D1, DCUN1L1, RP42, SCCRO, T4Tp126, e
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand H8S 1 x H8S
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 33.91Å b: 86.42Å c: 126.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.212 0.264
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Protein neddylation and its role in health and diseases.
Zhang et al. (2024)
4 more

1 mention without citation

Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity.
Zhou et al. (2021)