6xq0

X-ray diffraction
2.3Å resolution

Human antibody S8V2-18 in complex with the influenza hemagglutinin head domain of A/California/7/2009(NYMC-X181)(H1N1)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-271308 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin Chains: A, D
Molecule details ›
Chains: A, D
Length: 225 amino acids
Theoretical weight: 25.2 KDa
Source organism: Influenza A virus (A/reassortant/NYMC X-181A(A/NYMC X-157 x California/07/2009)(H1N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: I6T519 (Residues: 65-281; Coverage: 38%)
Gene name: HA
Sequence domains: Haemagglutinin
antibody S8V2-18 light chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 215 amino acids
Theoretical weight: 23.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
antibody S8V2-18 heavy chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 240 amino acids
Theoretical weight: 25.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 160.2Å b: 55.26Å c: 168Å
α: 90° β: 95.02° γ: 90°
R-values:
R R work R free
0.224 0.222 0.268
Expression systems:
  • Trichoplusia ni
  • Homo sapiens