› 6ybl

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein Chain: A
Molecule details ›
Chain: A
Length: 518 amino acids
Theoretical weight: 57.23 KDa
Source organisms: Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
  • Canonical: Q07820 (Residues: 173-321; Coverage: 43%)
Gene names: BCL2L3, JW3994, MCL1, b4034, malE
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
1 bound ligand:
Ligand OK5 1 x OK5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21212
Unit cell:
a: 99.21Å b: 137.46Å c: 38.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.228
Expression system: Escherichia coli BL21

Quick links

Citations

10 review citations

The multiple mechanisms of MCL1 in the regulation of cell fate.
Widden et al. (2021)
9 more

2 mentions without citation

Targeting MCL-1 in cancer: current status and perspectives.
Wang et al. (2021)
1 more