› 6yjm

X-ray diffraction
2.25Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193989 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
A disintegrin and metalloproteinase with thrombospondin motifs 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 223 amino acids
Theoretical weight: 24.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UNA0 (Residues: 264-481; Coverage: 24%)
Gene names: ADAMTS11, ADAMTS5, ADMP2
Sequence domains: Reprolysin (M12B) family zinc metalloprotease

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand CA 6 x CA
Ligand OU5 2 x OU5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 44.32Å b: 80.24Å c: 51.05Å
α: 90° β: 90.2° γ: 90°
R-values:
R R work R free
0.215 0.212 0.256
Expression system: Homo sapiens

Quick links

Citations

11 review citations

The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date.
Oo et al. (2021)
10 more

2 mentions without citation

Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition.
Cuffaro et al. (2022)
1 more