› 6yma

Electron crystallography
2.5Å resolution

MicroED structure of acetazolamide-bound human carbonic anhydrase II

Released:
DOI: 10.2210/pdb6yma/pdb
PDB entry 6yma coloured by chain, front view.
PDB entry 6yma coloured by chain, side view.
PDB entry 6yma coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Visualizing drug binding interactions using microcrystal electron diffraction.
Clabbers MTB, Fisher SZ, Coinçon M, Zou X, Xu H
OpenAccess logo Commun Biol 3 417 (2020)
PMID: 32737395

Function and Biology Details

Reactions catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Urea = cyanamide + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133681 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand AZM 1 x AZM
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Fragment-to-Lead Medicinal Chemistry Publications in 2020.
de Esch et al. (2022)
7 more

1 mention without citation

Electron Diffraction of 3D Molecular Crystals.
Saha et al. (2022)