› 6yrb

X-ray diffraction
2.35Å resolution

Crystal structure of the tetramerization domain of the glycoprotein Gn (Andes virus) at pH 7.5

Released:
DOI: 10.2210/pdb6yrb/pdb
PDB entry 6yrb coloured by chain, front view.
PDB entry 6yrb coloured by chain, side view.
PDB entry 6yrb coloured by chain, top view.
Source organisms:
Primary publication:
The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism.
Serris A, Stass R, Bignon EA, Muena NA, Manuguerra JC, Jangra RK, Li S, Chandran K, Tischler ND, Huiskonen JT, Rey FA, Guardado-Calvo P
Cell 183 442-456.e16 (2020)
PMID: 32937107

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190129 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (3 distinct):
Glycoprotein N Chains: A, B
Molecule details ›
Chains: A, B
Length: 149 amino acids
Theoretical weight: 15.94 KDa
Source organism: Andes orthohantavirus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9E006 (Residues: 375-484; Coverage: 10%)
Gene names: ADT63_77597gpM, ADT63_77598gpM, GP
Sequence domains: Hantavirus glycoprotein Gn, base
RNA (5'-D(*())-R(P*UP*UP*UP*())-3') Chains: C, D
Molecule details ›
Chains: C, D
Length: 5 nucleotides
Theoretical weight: 1.53 KDa
Source organism: Drosophila melanogaster

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
1 bound ligand:
Ligand IOD 6 x IOD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: I4
Unit cell:
a: 67.854Å b: 67.854Å c: 121.891Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.266
Expression system: Drosophila melanogaster

Quick links

Citations

9 review citations

The Bunyavirales: The Plant-Infecting Counterparts.
Kormelink et al. (2021)
8 more

2 mentions without citation

Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure.
Hulswit et al. (2021)
1 more