› 6ysc

X-ray diffraction
2.05Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143678 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin gamma-1 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 227 amino acids
Theoretical weight: 25.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOX5 (Residues: 223-449; Coverage: 51%)
Sequence domains: Immunoglobulin C1-set domain
Immunoglobulin gamma-1 heavy chain Chain: B
Molecule details ›
Chain: B
Length: 241 amino acids
Theoretical weight: 26.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOX5 (Residues: 223-449; Coverage: 51%)
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 49.361Å b: 80.357Å c: 141.826Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.293
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Ten years in the making: application of CrossMab technology for the development of therapeutic bispecific antibodies and antibody fusion proteins.
Surowka et al. (2021)
5 more

1 mention without citation

Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices.
Dengl et al. (2020)