› 6yxg

X-ray diffraction
3.01Å resolution

Cryogenic human adiponectin receptor 2 (ADIPOR2) with Tb-XO4 ligand determined by Serial Crystallography (SSX) using CrystalDirect

Released:
DOI: 10.2210/pdb6yxg/pdb
PDB entry 6yxg coloured by chain, front view.
PDB entry 6yxg coloured by chain, side view.
PDB entry 6yxg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An automated platform for structural analysis of membrane proteins through serial crystallography.
Healey RD, Basu S, Humm AS, Leyrat C, Cong X, Golebiowski J, Dupeux F, Pica A, Granier S, Márquez JA
OpenAccess logo Cell Rep Methods 1 None (2021)
PMID: 34723237

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-567294 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Adiponectin receptor protein 2 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.1 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q86V24 (Residues: 100-386; Coverage: 74%)
Gene names: ADIPOR2, PAQR2
Sequence domains: Haemolysin-III related
V REGION HEAVY AND LIGHT CHAINS Chain: H
Molecule details ›
Chain: H
Length: 236 amino acids
Theoretical weight: 25.42 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster

Ligands and Environments

4 bound ligands:
Ligand ZN 1 x ZN
Ligand OLA 1 x OLA
Ligand OLB 10 x OLB
Ligand 7MT 2 x 7MT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Unit cell:
a: 74.61Å b: 100.69Å c: 110.51Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.212 0.252
Expression system: Drosophila melanogaster

Quick links

Citations

4 citation in other articles

Rational design of the zonulin inhibitor AT1001 derivatives as potential anti SARS-CoV-2.
Di Micco et al. (2022)
3 more

1 mention without citation

An automated platform for structural analysis of membrane proteins through serial crystallography.
Healey et al. (2021)