› 6z30

X-ray diffraction
1.5Å resolution

Human cation-independent mannose 6-phosphate/ IGF2 receptor domains 9-10

Released:
DOI: 10.2210/pdb6z30/pdb
PDB entry 6z30 coloured by chain, front view.
PDB entry 6z30 coloured by chain, side view.
PDB entry 6z30 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.
Bochel AJ, Williams C, McCoy AJ, Hoppe HJ, Winter AJ, Nicholls RD, Harlos K, Jones EY, Berger I, Hassan AB, Crump MP
Structure 28 1300-1312.e5 (2020)
PMID: 32877646

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145907 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Cation-independent mannose-6-phosphate receptor Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 33.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11717 (Residues: 1222-1510; Coverage: 12%)
Gene names: IGF2R, MPRI
Sequence domains: Cation-independent mannose-6-phosphate receptor repeat

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 40.36Å b: 55.83Å c: 132.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.199 0.228
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Integrating intracellular nanovesicles into integrin trafficking pathways and beyond.
Larocque et al. (2022)
1 more

2 mentions without citation

Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.
Gorelik et al. (2022)
1 more