› 6z5d

X-ray diffraction
1.75Å resolution

Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004082

Released:
DOI: 10.2210/pdb6z5d/pdb
PDB entry 6z5d coloured by chain, front view.
PDB entry 6z5d coloured by chain, side view.
PDB entry 6z5d coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Benderitter P, Hoflack J, Denis A, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-570236 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase haspin Chain: A
Molecule details ›
Chain: A
Length: 357 amino acids
Theoretical weight: 40.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8TF76 (Residues: 465-798; Coverage: 42%)
Gene names: GSG2, HASPIN
Sequence domains: Haspin like kinase domain

Ligands and Environments

5 bound ligands:
Ligand MPD 2 x MPD
Ligand DMS 1 x DMS
Ligand SIN 1 x SIN
Ligand Q8Q 1 x Q8Q
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 78.357Å b: 78.839Å c: 81.055Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.153 0.178
Expression system: Escherichia coli BL21(DE3)

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