› 6zph

Electron Microscopy
6.9Å resolution

Kinesin binding protein complexed with Kif15 motor domain

Released:
DOI: 10.2210/pdb6zph/pdb
PDB entry 6zph coloured by chain, front view.
PDB entry 6zph coloured by chain, side view.
PDB entry 6zph coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The mechanism of kinesin inhibition by kinesin-binding protein.
Atherton J, Hummel JJ, Olieric N, Locke J, Peña A, Rosenfeld SS, Steinmetz MO, Hoogenraad CC, Moores CA
OpenAccess logo Elife 9 (2020)
PMID: 33252036
Related structures: EMD-11339

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188458 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
KIF-binding protein Chain: A
Molecule details ›
Chain: A
Length: 621 amino acids
Theoretical weight: 71.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96EK5 (Residues: 1-621; Coverage: 100%)
Gene names: KBP, KIAA1279, KIF1BP, KIFBP
Sequence domains: KIF-1 binding protein C terminal
Kinesin-like protein KIF15 Chain: B
Molecule details ›
Chain: B
Length: 383 amino acids
Theoretical weight: 41.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NS87 (Residues: 1-374; Coverage: 27%)
Gene names: KIF15, KLP2, KNSL7
Sequence domains: Kinesin motor domain

Ligands and Environments

2 bound ligands:
Ligand ADP 1 x ADP
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.9Å
Relevant EMDB volumes: EMD-11339
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Motor proteins at the mitochondria-cytoskeleton interface.
Kruppa et al. (2021)
4 more

2 mentions without citation

The mechanism of kinesin inhibition by kinesin-binding protein.
Atherton et al. (2020)
1 more