› 6zzw

X-ray diffraction
1.9Å resolution

Structure of the N terminal domain of Bc2L-C lectin (1-131) in complex with Globo H (H-type 3) and CAS No 912569-62-1

Released:
DOI: 10.2210/pdb6zzw/pdb
PDB entry 6zzw coloured by chain, front view.
PDB entry 6zzw coloured by chain, side view.
PDB entry 6zzw coloured by chain, top view.
Source organism: Burkholderia cenocepacia J2315
Primary publication:
Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia*.
Lal K, Bermeo R, Cramer J, Vasile F, Ernst B, Imberty A, Bernardi A, Varrot A, Belvisi L
OpenAccess logo Chemistry 27 10341-10348 (2021)
PMID: 33769626

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-502821 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Lectin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 134 amino acids
Theoretical weight: 14.01 KDa
Source organism: Burkholderia cenocepacia J2315
Expression system: Escherichia coli
UniProt:
  • Canonical: B4EH86 (Residues: 1-132; Coverage: 49%)
Gene name: BCAM0185
Sequence domains: Bc2l-C, N-terminal domain

Ligands and Environments

Carbohydrate polymer : NEW Components: GAL, GLA, NGA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: GAL, GLA, NGA, FUC
Carbohydrate polymer
2 bound ligands:
Ligand QT5 3 x QT5
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 74.459Å b: 42.912Å c: 103.345Å
α: 90° β: 96.1° γ: 90°
R-values:
R R work R free
0.184 0.181 0.238
Expression system: Escherichia coli

Quick links

Citations

1 review citation

From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?
Guo et al. (2023)
3 other articles

2 mentions without citation

Glycomimetics for the inhibition and modulation of lectins.
Leusmann et al. (2023)
1 more