Function and Biology

R1EN(5-227)-ubiquitin fusion

Source organisms:
Biochemical function: catalytic activity
Biological process: not assigned
Cellular component: not assigned

EC 2.7.7.49: RNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • DNA nucleotidyltransferase (RNA-directed)
  • RNA revertase
  • RNA-dependent DNA polymerase
  • RNA-dependent deoxyribonucleate nucleotidyltransferase
  • RNA-instructed DNA polymerase
  • RT
  • Reverse transcriptase
  • Revertase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Reverse transcriptase domain-containing protein; Ubiquitin
The deposited structure of PDB entry 6a44 contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Reverse transcriptase domain-containing protein. Showing 1 copy in chain A.

PF14529
Domain description: Endonuclease-reverse transcriptase
Occurring in:
  1. Reverse transcriptase domain-containing protein; Ubiquitin
The deposited structure of PDB entry 6a44 contains 1 copy of Pfam domain PF14529 (Endonuclease-reverse transcriptase ) in Reverse transcriptase domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Reverse transcriptase domain-containing protein; Ubiquitin
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Reverse transcriptase domain-containing protein; Ubiquitin
IPR036691
Domain description: Endonuclease/exonuclease/phosphatase superfamily
Occurring in:
  1. Reverse transcriptase domain-containing protein; Ubiquitin
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Reverse transcriptase domain-containing protein; Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Reverse transcriptase domain-containing protein; Ubiquitin
IPR005135
Domain description: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. Reverse transcriptase domain-containing protein; Ubiquitin